Exploring Spravato Treatment: A Revolutionary Approach to Depression

by | Apr 16, 2024

If you or a loved one has struggled with treatment-resistant depression, you know how frustrating and disheartening it can be to try medication after medication without finding relief. The good news is that there’s a revolutionary new treatment option called Spravato (esketamine) that offers hope for those who haven’t responded to traditional antidepressants.

What is Spravato?

Spravato is a nasal spray form of ketamine, a medication that has been used as an anesthetic for decades. However, in lower doses, ketamine has been found to have rapid and robust antidepressant effects, even in cases of severe, treatment-resistant depression (Johnson et al., 2020).

Spravato works by targeting the N-methyl-D-aspartate (NMDA) receptor in the brain, which is involved in regulating mood, cognition, and pain perception. By blocking this receptor, Spravato is thought to promote the growth of new neural connections and increase the release of neurotransmitters like glutamate and GABA, which can improve mood and alleviate depression symptoms (Daly et al., 2019).


“It was like a fog had lifted. I felt like myself again for the first time in years.”

A Life-Changing Treatment

For many individuals, Spravato has been a game-changer. Take the case of Sarah, a 42-year- old mother of two who had been battling severe depression for over a decade. Despite trying numerous antidepressants and therapy, her symptoms persisted, leaving her feeling hopeless and disconnected from her family.

After starting Spravato treatment, Sarah experienced a remarkable transformation. Within just a few weeks, her mood began to lift, and she found herself regaining interest in activities she once enjoyed. “It was like a fog had lifted,”  she recalls. “I felt like myself again for the first time in years.”

Sarah’s story is not unique. According to a study published in the American Journal of Psychiatry, Spravato combined with an oral antidepressant was significantly more effective than a placebo in reducing depression symptoms in patients with treatment-resistant depression (Popova et al., 2019).

A Compassionate Approach

At our practice, we understand the profound impact that depression can have on individuals and their loved ones. That’s why we approach Spravato treatment with a deep sense of compassion and empathy.

Our team of experienced mental health professionals will work closely with you to determine if Spravato is the right treatment option for your unique situation. We’ll provide comprehensive support throughout the process, ensuring that you feel safe, comfortable, and fully informed every step of the way.

If you or someone you love has been struggling with treatment-resistant depression, we encourage you to explore Spravato as a potential solution. With its revolutionary approach and promising results, this innovative treatment offers hope for a brighter, more fulfilling future.

Remember, you are not alone in this journey. Our compassionate team is here to support you every step of the way.

Johnson, J. W., Kotermanski, S. E., & Schiffer, W. K. (2020). Ketamine and its metabolites: Effective alternatives for treating severe depression. Pharmacology & Therapeutics, 215, 107628.
Daly, E. J., Singh, J. B., Fedgchin, M., Cooper, K., Lim, P., Shelton, R. C., … & Drevets, W. C. (2019). Efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression: a randomized clinical trial. JAMA psychiatry, 76(2), 139-149.
Popova, V., Daly, E. J., Trivedi, M., Cooper, K., Lane, R., Lim, P., … & Singh, J. B. (2019). Efficacy and safety of flexibly dosed esketamine nasal spray combined with a newly initiated oral antidepressant in treatment-resistant depression: a randomized double-blind active- controlled study. American Journal of Psychiatry, 176(6), 428-438.